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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
24.55
Human Site:
S625
Identified Species:
38.57
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S625
Q
E
G
L
I
P
G
S
Q
F
W
D
A
S
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S625
Q
E
G
L
I
P
G
S
Q
F
W
D
A
S
K
Dog
Lupus familis
XP_531814
1283
145094
S599
G
L
T
P
G
E
K
S
E
L
A
L
S
A
L
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S624
Q
E
G
L
I
P
G
S
Q
F
W
D
A
T
K
Rat
Rattus norvegicus
XP_002726765
1361
151628
S627
Q
E
G
L
I
P
G
S
Q
F
W
D
A
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
S731
Q
E
G
L
I
S
G
S
Q
F
W
S
A
S
K
Frog
Xenopus laevis
NP_001089247
1340
149481
S604
Q
E
S
L
Q
P
T
S
Q
F
W
D
A
S
R
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
G624
L
Q
E
G
L
N
A
G
S
Q
F
W
D
A
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
T520
D
M
D
H
L
G
L
T
P
N
D
N
Y
K
L
Honey Bee
Apis mellifera
XP_392346
1120
127429
N450
S
S
S
T
T
L
K
N
L
H
E
G
D
Y
F
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
T516
S
I
L
P
K
P
S
T
D
W
Q
L
A
L
S
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
V597
G
G
E
S
V
Y
G
V
C
I
V
E
T
S
I
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
Q606
G
S
L
Y
Y
L
K
Q
A
F
L
D
E
T
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
W598
L
V
P
L
S
E
F
W
D
S
E
K
T
I
Y
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
G572
L
K
S
Y
Y
D
T
G
K
K
V
G
F
S
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
6.6
N.A.
93.3
93.3
N.A.
N.A.
86.6
73.3
0
N.A.
0
0
13.3
13.3
P-Site Similarity:
100
N.A.
100
26.6
N.A.
100
100
N.A.
N.A.
86.6
80
33.3
N.A.
20
6.6
26.6
26.6
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
13.3
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
20
N.A.
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
0
7
0
7
0
47
14
7
% A
% Cys:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
7
0
7
0
0
7
0
0
14
0
7
40
14
0
0
% D
% Glu:
0
40
14
0
0
14
0
0
7
0
14
7
7
0
0
% E
% Phe:
0
0
0
0
0
0
7
0
0
47
7
0
7
0
7
% F
% Gly:
20
7
34
7
7
7
40
14
0
0
0
14
0
0
0
% G
% His:
0
0
0
7
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
0
7
0
0
34
0
0
0
0
7
0
0
0
7
7
% I
% Lys:
0
7
0
0
7
0
20
0
7
7
0
7
0
7
34
% K
% Leu:
20
7
14
47
14
14
7
0
7
7
7
14
0
7
20
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
7
0
7
0
7
0
0
0
% N
% Pro:
0
0
7
14
0
40
0
0
7
0
0
0
0
0
0
% P
% Gln:
40
7
0
0
7
0
0
7
40
7
7
0
0
0
7
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% R
% Ser:
14
14
20
7
7
7
7
47
7
7
0
7
7
40
7
% S
% Thr:
0
0
7
7
7
0
14
14
0
0
0
0
14
20
0
% T
% Val:
0
7
0
0
7
0
0
7
0
0
14
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
7
0
7
40
7
0
0
0
% W
% Tyr:
0
0
0
14
14
7
0
0
0
0
0
0
7
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _